| 新型血管紧张素转化酶抑制剂: 氮杂三肽类似物的合成及结构活性关系 |
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| 引用本文： | 刘世峰,徐杰诚. 新型血管紧张素转化酶抑制剂: 氮杂三肽类似物的合成及结构活性关系[J]. 化学学报, 1998, 56(7): 707-713 |
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| 作者姓名： | 刘世峰 徐杰诚 |
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| 作者单位： | 中国科学院上海有机化学研究所 |
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| 基金项目： | 国家自然科学基金，国家重点实验室基金，29232042，，， |
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| 摘 要： | 设计与合成一系列氮杂三肽类似物, 测定了氮杂三肽类似物对血管紧张素转化酶的体外抑制活性, 探讨了它们的结构与抑制活性之间的关系, 结果表明氮杂丙氨酸是丙氨酸很好的替代物。
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| 关 键 词： | 紫外分光光度法 降压药 元素分析 质子磁共振谱法 血管紧张素转化酶 氮杂三肽类似物 |
| 修稿时间： | 1997-03-28 |
Novel angiotensin converting enzyme inhibitors: Synthesis and structure-activity relationship of azatripeptide analogs |
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| LIU Shi-feng,XU Jie-Cheng. Novel angiotensin converting enzyme inhibitors: Synthesis and structure-activity relationship of azatripeptide analogs[J]. Acta Chimica Sinica, 1998, 56(7): 707-713 |
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| Authors: | LIU Shi-feng XU Jie-Cheng |
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| Abstract: | A series of azatripeptide analogs were designed and synthesized. The in vitro inhibitory activities of these compounds toward angiotensin converting enzyme (ACE) were evaluated. Furthermore,the structure - activity relationship of these compound was discussed. The results showed that azaalanine was a good isosterer of alanine in angiotensin converting enzyme inhibitors. |
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| Keywords: | angiotensin converting enzyme azatripeptide analogs blood pressure lowering agents |
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