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Anticancer drug release from poly(N-isopropylacrylamide/itaconic acid) copolymeric hydrogels |
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| Authors: | B. Ta delen, N. Kayaman-Apohan, O. Gü ven,B.M. Baysal |
| Affiliation: | aChemistry Department, Çekmece Nuclear Research and Training Center, P.O. Box 1, 34831 Istanbul, Turkey bDepartment of Chemistry, Marmara University, 81040 Göztepe/İstanbul, Turkey cDepartment of Chemistry, Hacettepe University, 06532 Beytepe/Ankara, Turkey dTUBITAK Marmara Research Center, Research Institute of Materials and Chemical Technologies, 41470 Gebze, Kocaeli, Turkey eDepartment of Chemical Engineering, Bogˇaziçi University, 80815 İstanbul, Turkey |
| Abstract: | The drug uptake and release of anticancer drug from N-isopropylacrylamide/itaconic acid copolymeric hydrogels containing 0–3 mol% of itaconic acid irradiated at 48 kGy have been investigated. 5-Fluorouracil (5-FU) is used as a model anticancer drug. The effect of 5-FU solution on swelling characteristics of PNIPAAm and P(NIPAAm/IA) copolymeric hydrogels have also been studied. The percent swelling, equilibrium swelling, equilibrium water/5-FU content and diffusion constant values are evaluated for poly(N-isopropylacrylamide) (PNIPAAm) and poly(N-isopropylacrylamide/itaconic) (P(NIPAAm/IA)) hydrogels at 130 ppm of 5-FU solution at room temperature. Diffusion of 5-FU solution into the hydrogels has been found to be the non-Fickian type. Finally, the kinetics of drug release from the hydrogels are examined. |
| Keywords: | Hydrogel N-isopropylacrylamide Itaconic acid 5-Fluorouracil Drug release |
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