Effect of voluntary running on adult hippocampal neurogenesis in cholinergic lesioned mice |
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Authors: | New Fei Ho Siew Ping Han and Gavin S Dawe |
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Institution: | (1) Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Centre for Life Sciences (CeLS), Level 4, 28 Medical Drive, 117456, Singapore |
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Abstract: | Background Cholinergic neuronal dysfunction of the basal forebrain is observed in patients with Alzheimer's disease and dementia, and
has been linked to decreased neurogenesis in the hippocampus, a region involved in learning and memory. Running is a robust
inducer of adult hippocampal neurogenesis. This study aims to address the effect of running on hippocampal neurogenesis in
lesioned mice, where septohippocampal cholinergic neurones have been selectively eliminated in the medial septum and diagonal
band of Broca of the basal forebrain by infusion of mu-p75-saporin immunotoxin. |
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Keywords: | |
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