Uracyl derivatives functionalized with N-, S-, O-heterocycles |
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Authors: | E S Krylova V E Semenov I V Galyametdinova V D Akamsin D R Sharafutdinova V S Reznik |
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Institution: | 1.Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center,Russian Academy of Sciences,Kazan,Russia |
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Abstract: | Reactions of 1,3-bis(bromopentyl)-5(6)-substituted uracyls with a series of five-membered heterocycles containing in the ring
N, S, or O atoms and a mercapto group as a substituent at the carbon atom of the ring afforded uracyl derivatives of acyclic
and macrocyclic structure with 2-thiobenzoxazole, 2-thio-5-methyl-1,3,4-thiadiazole, 2-thiobenzimidazole, and 2,5-dithio-1,3,4-thiadiazole
fragments. N atoms of benzoxazole and imidazole fragments of compounds obtained undergo alkylation and quaternization with
alkyl iodides and alkyl tosylates. |
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