| 叶酸接枝聚乙二醇化壳聚糖衍生物的合成 |
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| 引用本文： | 陶凤,席隆一,邓胜伟,余园园,李瑛.叶酸接枝聚乙二醇化壳聚糖衍生物的合成[J].化学研究与应用,2010,22(2). |
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| 作者姓名： | 陶凤 席隆一 邓胜伟 余园园 李瑛 |
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| 作者单位： | 四川大学化学学院,四川,成都,610064 |
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| 基金项目： | 四川大学学生科研训练计划项目资助 |
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| 摘 要： | 本文通过邻苯二甲酸酐保护壳聚糖的2-NH2,在壳聚糖的6-OH上引入聚乙二醇单甲醚。再经脱保护基团、2-NH2挂接叶酸,合成了叶酸接枝的聚乙二醇化壳聚糖。目标物用FT-IR,1HNMR,UV-Vis进行了表征。
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| 关 键 词： | 壳聚糖 叶酸 聚乙二醇单甲醚 合成 |
Synthesis of O-PEG-N-folate-chitosan derivatives |
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| TAO Feng,XI Long-yi,DENG Sheng-wei,YU Yuan-yuan,LI Ying.Synthesis of O-PEG-N-folate-chitosan derivatives[J].Chemical Research and Application,2010,22(2). |
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| Authors: | TAO Feng XI Long-yi DENG Sheng-wei YU Yuan-yuan LI Ying |
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| Abstract: | mPEG and folic acid were grafted into chitosan for potential gene carrier for tumor cells.N-phthaloyl chitosan was prepared for protected amino groups of chitosan,then N-phthaloyl chitosan was reacted with MPEG iodide and removed N-phthaloyl group subsequently.Finally,the folic acid was grafted to the amino group of chitosan and O-mPEG-N-folate-chitosan derivative was prepared. The structures of chitosan and its derivatives were characterized and confirmed by ~1H NMR,FT-IR and UV-Vis spectroscopy.O-mPEG-N-folate-chitosan may be used as potential gene carrier for tumor cells. |
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| Keywords: | chitosan folic acid monomethoxy poly(ethylene glycol) synthesis |
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