Enantioselective synthesis of secondary alcohols in the presence of chiral ligands |
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| Authors: | L Colombo C Gennari G Poli C Scolastico |
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| Institution: | Centro C.N.R. per le Sostanze Organische Naturali, Instituto di Chimica Organica dell''Università, via Venezian 21, 20133 Milano, Italy |
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| Abstract: | The synthesis of two S-proline derivatives is described together with their use as chiral ligands for lithium in reactions of n-butyllithium with benzaldehyde to give 1-phenyl-1-pentanol with moderate optical purity. The presence of lithium salts in the reaction mixture causes a decrease in asymmetric induction. |
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