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Regiocontrolled synthesis of substituted thiazoles |
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| Authors: | Hodgetts Kevin J Kershaw Mark T |
| Affiliation: | Neurogen Corporation, 35 Northeast Industrial Road, Branford, Connecticut 06405, USA. khodgetts@nrgn.com |
| Abstract: | The regiocontrolled synthesis of 2,5-disubstituted and 2,4,5-trisubstituted thiazoles from ethyl 2-bromo-5-chloro-4-thiazolecarboxylate 1 using sequential palladium-catalyzed coupling reactions is described. [reaction: see text] |
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