2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations |
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| Authors: | Wu Xiaolin Delgado Guillermo Krishnamurthy Ramanarayanan Eschenmoser Albert |
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| Affiliation: | The Skaggs Institute for Chemical Biology at the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. |
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| Abstract: | Replacement of adenine by 2,6-diaminopurine-two nucleobases to be considered equivalent from an etiological point of view-strongly enhances the stability of TNA/TNA, TNA/RNA, or TNA/DNA duplexes and efficiently accelerates template-directed ligation of TNA ligands. [reaction: see text] |
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