9-BBN: An amino acid protecting group for functionalization of amino acid side chains in organic solvents |
| |
Authors: | Dent William H Erickson W Randal Fields Stephen C Parker Marshall H Tromiczak Eric G |
| |
Affiliation: | Discovery Research, Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN 46268-1054, USA.. |
| |
Abstract: | 9-Borabicyclononane (9-BBN) has been utilized to protect functionalized amino acids for potential chemoselective side chain manipulation. The 9-BBN group imparts organic solubility to otherwise hydrophilic molecules and is tolerant of a wide range of reaction conditions. The high degree of solubility of these molecules in THF is particularly noteworthy. It is cleaved with either aqueous HCl or by exchange with ethylenediamine in methanol. [reaction: see text] |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|