Stereoselective synthesis of functionalized gamma-amino esters: azetidinium salts and epoxy esters |
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| Authors: | Concellón José M Riego Estela Bernad Pablo L |
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| Affiliation: | Departamento de Química Orgánica e Inorgánica, Facultad de Química, Universidad de Oviedo, Julián Clavería 8, 33071 Oviedo, Spain. jmcg@sauron.quimica.uniovi.es |
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| Abstract: | Addition of several lithium ester enolates to chiral 1-aminoalkyl chloromethyl ketones 1 affords enantiomerically pure 3-hydroxyazetidinium salts 3 or 3-(1'-aminoalkyl)-3,4-epoxy esters 4, depending on the reaction conditions. [reaction: see text] |
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