Enantioselective monoreduction of 2-alkyl-1,3-diketones mediated by chiral ruthenium catalysts. dynamic kinetic resolution |
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| Authors: | Eustache Florence Dalko Peter I Cossy Janine |
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| Institution: | Laboratoire de Chimie Organique associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France. |
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| Abstract: | The reduction of 2-alkyl-1,3-diketones using (R,R)- or (S,S)-RuClN-(tosyl)-1,2-diphenylethylenediamine](p-cymene) in the presence of formic acid and triethylamine affords syn-2-alkyl-3-hydroxy ketones as the major products with high enantioselectivity. reaction: see text] |
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