Microbial transformation of kawain and methysticin |
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Authors: | Abourashed E A Khan I A |
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Institution: | National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences and Department of Phlarmacognosy, School of Pharmacy, The University of Mississippi, University 38677, USA. |
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Abstract: | The styryl alpha-pyrones, d-kawain (1) and d-methysticin (2) are two of the major kavalactone constituents of the anxiolvtic herb Piper methysticum, commonly known as kava. The use of fungal models to mimic the mammalian metabolism of 1 resulted in the production of 4'-hydroxykawain (1a) from the culture broth of Cunninghamella elegans (ATCC 9245), the same metabolite identified in rat urine. The fungus Torulopsis petrophilum (ATCC 20225) biotransformed 2 to 3'-hydroxy-4'-methoxykawain (2c) which is analogous, but not identical, to a known rat metabolite of methysticin. |
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