Cooperative translocation dynamics of biopolymer chains through nanopores in a membrane: Slow dynamics limit |
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Authors: | Wang Hai-Jun Gu Fang Hong Xiao-Zhong Ba Xin-Wu |
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Institution: | (1) Department of Biomedical Engineering and Department of Physics, Boston University, Boston, MA 02215, USA; |
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Abstract: | The cooperative translocation dynamics of two complementary single-stranded DNA chains through two nanopores located in a
membrane is investigated theoretically. The translocation process is considered to be quasi-equilibrium, and then under the
limit of slow dynamics the average translocation times are numerically presented under different conditions. It is shown that the effects of the
chemical potential gradient, the recombination energy and the distance between the two nanopores on the cooperative translocation
are significant. The present model predicts that the cooperative translocation of such two chains can shorten the translocation
time, reduce the backward motion and thus improve the translocation efficiency. |
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Keywords: | |
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