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Monitoring of optical isomers of β-methylphenylalanine in opioid peptides |
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| Authors: | Antal P ter, G za T th, Erzs bet Cserp n,Dirk Tourw |
| Affiliation: | Department of Inorganic and Analytical Chemistry, Attila József University, P.O. Box 440, H-6701 Szeged Hungary Hungarian Academy of Sciences, Biological Research Centre, Isotope Laboratory “B” Level, P.O. Box 521, H-6721 Szeged Hungary Eenheid Organische Chemie, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels Belgium |
| Abstract: | -erythro- and -threo-β-methylphenylalanines were synthesized and incorporated into the delta opioid receptor-selective deltorphin C peptide by solid-phase peptide synthesis. The enantiomeric composition of β-methylphenylalanine and the diastereomeric composition of the peptide were determined. To distinguish exactly between the two enantiomeric pairs of β-methylphenylalanine, different liquid, gas and thin-layer chromatographic methods are suggested, while the four diastereomers Of [β-Mephe3]deltorphin C Can be identified and separated conveniently by high-performance liquid chromatography. |
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