Lentinus edodes Polysaccharides Alleviate Acute Lung Injury by Inhibiting Oxidative Stress and Inflammation |
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Authors: | Yiwen Zhang Yanfei Cui Yanbo Feng Fengping Jiao Le Jia |
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Affiliation: | 1.College of Life Science, Shandong Agricultural University, Taian 271018, China;2.School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China |
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Abstract: | Acute lung injury (ALI) is a kind of lung disease with acute dyspnea, pulmonary inflammation, respiratory distress, and non-cardiogenic pulmonary edema, accompanied by the mid- and end-stage characteristics of COVID-19, clinically. It is imperative to find non-toxic natural substances on preventing ALI and its complications. The animal experiments demonstrated that Lentinus edodes polysaccharides (PLE) had a potential role in alleviating ALI by inhibiting oxidative stress and inflammation, which was manifested by reducing the levels of serum lung injury indicators (C3, hs-CRP, and GGT), reducing the levels of inflammatory factors (TNF-α, IL-1β, and IL-6), and increasing the activities of antioxidant enzymes (SOD and CAT) in the lung. Furthermore, PLE had the typical characteristics of pyran-type linked by β-type glycosidic linkages. The conclusions indicated that PLE could be used as functional foods and natural drugs in preventing ALI. |
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Keywords: | antioxidant activities anti-inflammatory acute lung injury Lentinula edodes polysaccharides pulmonary protection |
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