Croargoids A–G,Eudesmane Sesquiterpenes from the Bark of Croton argyratus |
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| Authors: | Min Wu Kai-Long Ji Peng Sun Jian-Mei Lu Jia-Rui Yue Dong-Hua Cao Chun-Fen Xiao You-Kai Xu |
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| Affiliation: | 1.Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Xishuangbanna 666303, China;2.University of Chinese Academy of Sciences, Beijing 100049, China;3.School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China;4.The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410004, China |
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| Abstract: | Seven new sesquiterpenes, named croargoid A–G (1–7), were isolated from the bark of Croton argyratus. Compounds 1–4 were the first examples of eudesmane sesquiterpene lactones containing C5-OH group. Compound 7 was a highly degraded eudesmane sesquiterpene possessing a rare eleven-carbon skeleton. Their structures with stereochemistry were mainly elucidated by NMR analyses in combination with MS and ECD data. Cytotoxicities and NO inhibitions of all isolates were evaluated and only compound 5 showed moderate NO inhibitory activity. |
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| Keywords: | Croton argyratus Euphorbiaceae eudesmane sesquiterpene NO inhibition |
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