Supramolecular Tools to Improve Wound Healing and Antioxidant Properties of Abietic Acid: Biocompatible Microemulsions and Emulgels |
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| Authors: | Alla Mirgorodskaya Rushana Kushnazarova Rais Pavlov Farida Valeeva Oksana Lenina Kseniya Bushmeleva Dmitry Kuryashov Alexandra Vyshtakalyuk Gulnara Gaynanova Konstantin Petrov Lucia Zakharova |
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| Affiliation: | 1.Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov Str. 8, 420088 Kazan, Russia;2.Kazan National Research Technological University, Karl Marx Str. 68, 420015 Kazan, Russia |
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| Abstract: | Abietic acid, a naturally occurring fir resin compound, that exhibits anti-inflammatory and wound-healing properties, was formulated into biocompatible emulgels based on stable microemulsions with the addition of a carbamate-containing surfactant and Carbopol® 940 gel. Various microemulsion and emulgel formulations were tested for antioxidant and wound-healing properties. The chemiluminescence method has shown that all compositions containing abietic acid have a high antioxidant activity. Using Strat-M® skin-modelling membrane, it was found out that emulgels significantly prolong the release of abietic acid. On Wistar rats, it was shown that microemulsions and emulgels containing 0.5% wt. of abietic acid promote the rapid healing of an incised wound and twofold tissue reinforcement compared to the untreated group, as documented by tensiometric wound suture-rupture assay. The high healing-efficiency is associated with a combination of antibacterial activity of the formulation components and the anti-inflammatory action of abietic acid. |
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| Keywords: | drug delivery systems emulgel microemulsion surfactant gelating polymer abietic acid antioxidant activity wound healing |
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