1,3,2-Oxazaphosphinane analogs of phosphorylacetic acid derivatives: synthesis and properties

Reactions of 2-AlkO-1,3,2-oxazaphosphinanes with alkyl N-haloacetylamino or N-chloromethyl-N-methoxycarbonylamino carboxylates mainly give products with retention (Alk = Me) and opening of the ring (Alk = Et). In aqueous solution, cyclic products with the N-isopropyl group are only stable, while the rest undergo hydrolysis with cleavage of the P-N bond of the ring. Oxazaphosphinane analogs of phosphorylacetamide and phosphorylacetohydrazide were synthesized.