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Novel Antifungal Dimers from the Roots of Taiwania cryptomerioides
Authors:Ming-Jen Cheng  Ming-Der Wu  Chao-Lin Chang  Hsun-Shuo Chang  Chiou-Fung Chyu  Yueh-Hsiung Kuo
Abstract:Five new dimer compounds, namely Taiwaniacryptodimers A–E (1–5), were isolated from the methanol extract of the roots of Taiwania cryptomerioides. Their structures were established by mean of spectroscopic analysis and comparison of NMR data with those of known analogues. Their antifungal activities were also evaluated. Our results indicated that metabolites 1, 2, 4, and 5 displayed moderate antifungal activities against Aspergillus niger, Penicillium italicum, Candida albicans, and Saccharomyces cerevisiae.
Keywords:Taiwania   cryptomerioides  Taxodiaceae  novel skeleton  dimer  diterpenoid  antifungal activities
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