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Biosynthesis of new polymers of controlled molecular structure |
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| Authors: | Michael J. Dougherty Srinivas Kothakota Mark T. Krejchi Guanghui Zhang Thomas L. Mason David A. Tirrell Maurille J. Fournier |
| Affiliation: | 1. Departments of Biochemistry and Molecular Biology University of Massachusetts, Amherst, MA 01003 USA Program in Molecular and Cellular Biology University of Massachusetts, Amherst, MA 01003 USA;2. Departments of Polymer Science and Engineering University of Massachusetts, Amherst, MA 01003 USA;3. Departments of Polymer Science and Engineering University of Massachusetts, Amherst, MA 01003 USA Program in Molecular and Cellular Biology University of Massachusetts, Amherst, MA 01003 USA |
| Abstract: | This paper describes the use of artificial genes to direct bacterial synthesis of new polypeptides of precisely defined molecular structure. This approach has been applied to three problems in polymer chemistry and physics: i) control of chain folding in crystalline polymers, ii) biosynthesis of polypeptides containing unnatural amino acids, and iii) preparation of monodisperse helical polymers. |
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