A Double-Site Chemodosimeter for Selective Fluorescence Detection of a Nerve Agent Mimic |
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| Authors: | Xin Guo Chang-Xiang Liu Yuan Lu Ya-Wen Wang Yu Peng |
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| Affiliation: | 1.School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China; (X.G.); (C.-X.L.);2.Chengdu Municipal Bureau of Economic and Information Technology, Chengdu 610229, China; |
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| Abstract: | A novel two-site chemodosimeter (SWJT-4) based on fluorescein skeleton to detect diethyl chlorophosphate (DCP) was designed and synthesized. It is a turn-on fluorescent probe for DCP with good selectivity and obvious color change in aqueous solution. Interestingly, the two oxime groups of SWJT-4 as dual response sites initiated different reactions with DCP to form a cyano group and an isoxazole ring, respectively. The corresponding mechanism was confirmed by 1H NMR, MS and DFT calculation. Moreover, SWJT-4 could be used as a fluorescent test paper to detect DCP vapor. |
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| Keywords: | fluorescence diethyl chlorophosphate (DCP) double-site chemodosimeter |
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