The Roles and Associated Mechanisms of Adipokines in Development of Metabolic Syndrome |
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| Authors: | Ji-Eun Kim Jin-Sun Kim Min-Jee Jo Eunjung Cho Shin-Young Ahn Young-Joo Kwon Gang-Jee Ko |
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| Institution: | 1.Department of Internal Medicine, Korea University Guro Hospital, Seoul 08308, Korea; (J.-E.K.); (J.-S.K.); (M.-J.J.); (E.C.); (S.-Y.A.); (Y.-J.K.);2.Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea |
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| Abstract: | Metabolic syndrome is a cluster of metabolic indicators that increase the risk of diabetes and cardiovascular diseases. Visceral obesity and factors derived from altered adipose tissue, adipokines, play critical roles in the development of metabolic syndrome. Although the adipokines leptin and adiponectin improve insulin sensitivity, others contribute to the development of glucose intolerance, including visfatin, fetuin-A, resistin, and plasminogen activator inhibitor-1 (PAI-1). Leptin and adiponectin increase fatty acid oxidation, prevent foam cell formation, and improve lipid metabolism, while visfatin, fetuin-A, PAI-1, and resistin have pro-atherogenic properties. In this review, we briefly summarize the role of various adipokines in the development of metabolic syndrome, focusing on glucose homeostasis and lipid metabolism. |
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| Keywords: | adipokine metabolic syndrome glucose intolerance lipid metabolism |
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