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Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors
Authors:Amarender Manchoju  Renaud Zelli  Gang Wang  Carla Eymard  Adrian Oo  Mona Nemer  Michel Prvost  Baek Kim  Yvan Guindon
Abstract:The design of novel nucleoside triphosphate (NTP) analogues bearing an all-carbon quaternary center at C2′ or C3′ is described. The construction of this all-carbon stereogenic center involves the use of an intramoleculer photoredox-catalyzed reaction. The nucleoside analogues (NA) hydroxyl functional group at C2′ was generated by diastereoselective epoxidation. In addition, highly enantioselective and diastereoselective Mukaiyama aldol reactions, diastereoselective N-glycosylations and regioselective triphosphorylation reactions were employed to synthesize the novel NTPs. Two of these compounds are inhibitors of the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, the causal virus of COVID-19.
Keywords:SARS-CoV-2  COVID-19  RdRp  quaternary stereocenter  nucleoside analogues  epoxidation  glycosylation  triphosphorylation
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