A readily synthesized cyclic pyrrolysine analogue for site-specific protein "click" labeling |
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| Authors: | Hao Ziyang Song Yanqun Lin Shixian Yang Maiyun Liang Yujie Wang Jing Chen Peng R |
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| Institution: | Beijing National Laboratory for Molecular Sciences (BNLMS), Department of Chemical Biology, College of Chemistry, Peking University, Beijing 100871, China. |
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| Abstract: | A concise route was developed for the facile synthesis of a cyclic pyrrolysine analogue bearing an azide handle. Directed evolution enabled the encoding of this non-natural amino acid in both prokaryotic and eukaryotic cells, which offers a highly efficient approach for the site-specific protein labeling using click chemistry. |
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