Controllable exploding microcapsules as drug carriers |
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| Authors: | Zhang Jing Li Cao Wang Ya Zhuo Ren-Xi Zhang Xian-Zheng |
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| Institution: | Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, PR China. |
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| Abstract: | Controllable exploding polyelectrolyte microcapsules were developed by layer-by-layer assembly of poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styrenesulfonate) (PSS) on a dextran microgel core containing a cleavable disulfide bond fabricated via click chemistry. The microcapsules can explode upon the injection of DTT with an explosive release of the drug. |
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