| Design, Synthesis and in vitro Evaluation of Thiazole Derivatives of Ibuprofen as Cyclooxygenase-2 Inhibitors |
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| 引用本文： | Chang Bin GUO Zhe Feng CAI Zong Ru GUO Zhi Qiang FENG Feng Ming CHU Gui-Fang CHENG. Design, Synthesis and in vitro Evaluation of Thiazole Derivatives of Ibuprofen as Cyclooxygenase-2 Inhibitors[J]. 中国化学快报, 2006, 17(3): 325-328 |
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| 作者姓名： | Chang Bin GUO Zhe Feng CAI Zong Ru GUO Zhi Qiang FENG Feng Ming CHU Gui-Fang CHENG |
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| 作者单位： | Chang Bin GUO，Zhe Feng CAI，Zong Ru GUO?，Zhi Qiang FENG，Feng Ming CHU，Gui Fang CHENG Institute of Materia Medica，Chinese Academy of Medical Science and Peking Union Medical College，Beijing 100050 |
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| 基金项目： | This project was supported by the National Natural Science Foundation of China（No 39770877）. We thank the analytical division of Institute of Materia Medica Chinese Academy of Medical Sciences for the spectroscopic measurement and elementary analysis, |
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| 摘 要： | Selective cyclooxygenase-2 (COX-2) inhibitors exhibite advantages for inflammation and pain relief without the gastrointestinal damage and hematologic liabilities observed with traditional non-steroidal anti-inflammatory drugs (NSAIDs) which can inhibit b…
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| 关 键 词： | 设计 合成 体外评价 噻唑衍生物 布洛芬 环氧酶-2抑制剂 |
| 收稿时间： | 2005-07-17 |
Design, Synthesis and in vitro Evaluation of Thiazole Derivatives of Ibuprofen as Cyclooxygenase-2 Inhibitors |
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| Chang Bin GUO,Zhe Feng CAI,Zong Ru GUO,Zhi Qiang FENG,Feng Ming CHU,Gui Fang CHENG. Design, Synthesis and in vitro Evaluation of Thiazole Derivatives of Ibuprofen as Cyclooxygenase-2 Inhibitors[J]. Chinese Chemical Letters, 2006, 17(3): 325-328 |
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| Authors: | Chang Bin GUO Zhe Feng CAI Zong Ru GUO Zhi Qiang FENG Feng Ming CHU Gui Fang CHENG |
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| Abstract: | A series of thiazole derivatives of ibuprofen, as cyclooxygenase-2 Inhibitors, were designed, synthesized and in vitro evaluated. |
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| Keywords: | Cyclooxygenase-2 (COX-2) inhibitor ibuprofen thiazole derivative. |
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