High-performance liquid chromatographic analysis of 2',3'-dideoxyinosine in biological samples |
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Authors: | M G Wientjes J L Au |
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Institution: | Division of Urology, Ohio State University, Columbus 43210. |
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Abstract: | A high-performance liquid chromatographic analysis for the anti-AIDS drug 2',3'-dideoxyinosine (ddI) in rat plasma and urine, with a limit of detection of 0.2 microgram/ml and requiring a sample size of 100 microliters is described. Diluted plasma or urine samples were extracted using a C18 solid-phase extraction column. Retention of ddI on more polar solid-phase extraction columns was insufficient for sample clean-up. This method is useful for pharmacokinetic studies of ddI in small rodents. |
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