Copper‐Catalyzed Synthesis of γ‐Amino Acids Featuring Quaternary Stereocenters |
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| Authors: | José Enrique Gómez Dr. Wusheng Guo Silvia Gaspa Prof. Dr. Arjan W. Kleij |
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| Affiliation: | 1. Institute of Chemical Research of Catalonia (ICIQ), the Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain;2. Catalan Institute of Research and Advanced Studies (ICREA), Pg. Lluís Companys 23, 08010 Barcelona, Spain |
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| Abstract: | The first general asymmetric synthesis of γ,γ‐disubstituted γ‐amino acids by copper‐catalyzed ring opening of nonstrained lactones with amines is reported. This approach features ample scope, operational simplicity, and wide functional‐group diversity. The catalytic process allows access to a series of highly functionalized enantioenriched γ‐amino acids featuring quaternary stereocenters with excellent enantiomeric ratios of up to 98:2 and excellent yields of up to 98 %. |
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| Keywords: | Aminosä uren Asymmetrische Synthesen Kupfer Lactame Mittlere Ringsysteme |
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