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Synthesis of [18F]Fluoroarenes by Nucleophilic Radiofluorination of N‐Arylsydnones
Abstract:A practical method for radiofluorination of anilines with 18F]fluoride via N ‐arylsydnone intermediates is described. These precursors are stable, easy to handle and facilitate direct and regioselective 18F‐labeling to prepare 18F]fluoroarenes. The value of this methodology is further highlighted by successful application to prepare an 18F‐labeled neuropeptide.
Keywords:Fluor-18  Fluorarene  Klickchemie  Peptidradiomarkierung  Sydnon
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