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Rhodium-catalyzed asymmetric hydrogenation of β-acetylamino acrylonitriles |
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| Authors: | Miaofeng Ma Guohua Hou Junru Wang Xumu Zhang |
| Institution: | a College of Science, Northwest Agriculture and Forestry University, Yangling, Shaanxi 712100, PR China;b Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA;c Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA |
| Abstract: | The rhodium-catalyzed asymmetric hydrogenation of β-acetylamino acrylonitriles was investigated by using monophosphine and bisphosphine ligands. It was found that an Rh-QuinoxP∗ complex exhibited high enantioselectivities for β-aryl substituted β-acetylamino acrylonitriles and the Rh-JosiPhos CyPF-t-Bu complex was proven to be effective for the hydrogenation of tetrasubstituted olefins from cyclic β-acetylamino acrylonitriles. |
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