全氟辛酸致小鼠肝脏氧化损伤的实验

研究了低（1mg/kg/d）、中（5mg/kg/d）、高（25mg/kg/d）三个剂量组全氟辛酸（Perfluorooctanoic acid,PFOA）致小鼠肝脏脂质过氧化损伤的作用.结果发现,PFOA能抑制小鼠体重的增长,对肝组织造成一定的脂质过氧化损伤.各组小鼠出现不同程度的体重增长缓慢甚至减轻,中、高剂量组出现明显的减轻（P＜0.01）；低、中、高剂量组肝脏系数,均明显高于对照组（P＜0.01）;与对照组相比,各剂量组的肝组织中MDA、NO及LDH含量明显增高,SOD、SDH及GSH-Px活性均明显降低（P＜0.05）.

The Experimental of Liver Oxidation Damage Induced by Perfluorooctanoic Acid in Mice

The oxidative damage of mouse liver was investigated by perfluorooctanoic acid （PFOA） in control, low-dosage group of PFOA （lmg/kg/day）, middle-dosage group of PFOA （5mg/kg/day） and high-dosage group of PFOA （25mg/kg/day） respectively. The body weight gain was inhibited and the liver tissues were oxidative damaged by PFOA. The body weight gain was reduced or even decreased by PFOA treatment at different doses for 14days （middle-dosage group and high-dosage group compared with the control group,P〈0.01. Liver indexes of mice of the different dosage groups were increased compared with the control group,P〈0.01. The content of MDA,NO and the activity of LDH in hepatic tissue of PFOA groups were increased dramatically, while the activity of SOD, GSH-Px and SDH was decreased obviously compared with the control group, P〈0. 05.