| 二阶导数光谱法测定溴新斯的明磷脂复合物的复合率 |
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| 引用本文： | 孙全,陈学梁,张景勍.二阶导数光谱法测定溴新斯的明磷脂复合物的复合率[J].光谱实验室,2013(6):3264-3267. |
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| 作者姓名： | 孙全 陈学梁 张景勍 |
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| 作者单位： | 重庆医科大学药物高校工程研究中心,重庆市渝中区医学院路1号400016 |
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| 基金项目： | 重庆市教育委员会资助项目（KJ090308） |
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| 摘 要： | 采用二阶导数光谱法测定溴新斯的明磷脂复合物的复合率,以264.2nm处测定振幅D值,测定溴新斯的明磷脂复合物中溴新斯的明的含量,由此计算复合率.结果表明,溴新斯的明在0.10-0.40mg·mL^-1浓度范围内线性关系良好,回归方程为y=0.3057x＋0.0053,r=0.9992;平均加样回收率为99.86％,RSD为1.16％（n=9）.此方法准确,简便,快速,适用于溴新斯的明磷脂复合物复合率的测定.
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| 关 键 词： | 溴新斯的明 磷脂复合物 二阶导数光谱法 复合率 |
Determination of Complexation Rate of Neostigmine Bromide-Phospholipid Complex by Second Derivative Spectrometry |
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| SUN Quan,CHENG Xue-Liang,ZHANG Jing-.Determination of Complexation Rate of Neostigmine Bromide-Phospholipid Complex by Second Derivative Spectrometry[J].Chinese Journal of Spectroscopy Laboratory,2013(6):3264-3267. |
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| Authors: | SUN Quan CHENG Xue-Liang ZHANG Jing- |
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| Institution: | Qing(Medicine Engineering Research Center ,Chongqing Medical University ,Chongqing 400016 , P. R. China) |
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| Abstract: | The complexation rate of neostigmine bromide-phospholipid was determined by second derivative spectrometry. The peak amplitude was determined when the wavelength was at 264.2nm. Then the complexation rate was calculated. The experiment had a good liner relationship range from 0.10 to 0.40mg · mL^-1 for neostigmine bromide content. The regression equation was as follow：y=0. 3057x＋0. 0053 ,r=0. 9992. The average recovery rate was 99.86% ,RSD was 1.16% （n=9）. The method was simple,accurate and rapid. It is suitable for the determination of the complexation rate of neostigmine bromide-phospholipid. |
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| Keywords: | Neostigmine Bromide Phospholipid Complex Second Derivative Spectrometry Complexation Rate |
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