| 海洋放线菌S592次级代谢产物及其体外抑菌活性研究 |
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| 引用本文： | 张冰,张娟利,李慧琳,黄之镨,赵庆,张晓梅. 海洋放线菌S592次级代谢产物及其体外抑菌活性研究[J]. 化学通报, 2022, 85(1): 116-121 |
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| 作者姓名： | 张冰 张娟利 李慧琳 黄之镨 赵庆 张晓梅 |
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| 作者单位： | 云南中医药大学,空军军医大学第一附属医院药剂科,空军军医大学第一附属医院药剂科,云南中医药大学,云南中医药大学,云南中医药大学 |
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| 基金项目： | 国家自然科学基金项目(21662048)和云南省科技计划项目(2017FF116(-002))资助 |
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| 摘 要： | 对海洋放线菌S592的次级代谢产物以及体外抑菌活性进行研究.将菌株S592进行大量发酵,采用色谱方法对菌株发酵产物进行分离纯化,通过波谱技术对所获单体化合物进行结构鉴定,并测定化合物的体外抑菌活性.从海洋放线菌S592中分离得到6个化合物,含2个螺环抗生素lobophorin类化合物,1个环肽类化合物,2个苯甲酰胺类化...
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| 关 键 词： | 海洋放线菌 次级代谢产物 分离鉴定 抗菌活性 耐甲氧西林金黄色葡萄球菌 |
| 收稿时间： | 2021-05-09 |
| 修稿时间： | 2021-06-08 |
Study on the Secondary Metabolites of Marine Actinomycetes S592 and Their Antibacterial Activity In Vitro |
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| zhang bing,zhang juanli,li huiling,huang zhipu,zhao qing and zhang xiaomei. Study on the Secondary Metabolites of Marine Actinomycetes S592 and Their Antibacterial Activity In Vitro[J]. Chemistry, 2022, 85(1): 116-121 |
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| Authors: | zhang bing zhang juanli li huiling huang zhipu zhao qing zhang xiaomei |
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| Affiliation: | (College of Basic Medicine,College of Traditional Chinese Medicine,Yunnan University of Chinese Medicine,Kunming,650500;Department of Pharmacy,the First Affiliated Hospital of Air Force Medical University,Xi'an,710032) |
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| Abstract: | The secondary metabolites and their antibacterial activities of marine actinomycetes S592 were studied. The strain S592 was fermented and the fermentation products were separated and purified by chromatography. The structures of the compounds were identified by spectroscopic techniques, and their antibacterial activities in vitro were determined. Six compounds were isolated from marine actinomycete S592, including two lobophorins, one cyclic peptide, two benzamides and one quinazolinone compound. All six compounds showed different inhibitory effects against at least one pathogen. Among them, six compounds had inhibitory activity on MRSA 28300, and four compounds had inhibitory activity on Mycobacterium smegmatis, the inhibitory activity of compounds 1 and 2 on MRSA was found for the first time. |
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| Keywords: | Marine actinomycetes Secondary metabolites Isolation and identification Antibacterial activities Methicillin-resistant staphylococcus aureus |
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