2,2,3,3,11,11,12,12-Octamethyl-1,4,7,10,13-pentaoxacyclohexadecane: improved synthesis and crystal structure with NaSCN |
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| Authors: | Fanny Loustau-Chartez Radu Custelcean Peter V Bonnesen |
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| Institution: | a Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6119, United States
b Momenta Pharmaceuticals, Cambridge, MA 02142, United States |
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| Abstract: | An efficient synthesis of 2,2,3,3,11,11,12,12-octamethyl-1,4,7,10,13-pentaoxacyclohexadecane (1, OM16C5) is described, which affords over an order of magnitude improvement in yield over the previously reported method. The first X-ray crystal structure of 1, as a complex with NaSCN, is also reported. |
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| Keywords: | Crown ether Improved synthesis 16-Crown-5 Sodium |
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