A simple one-pot synthesis of functionalised 6-(indol-3-yl)-2,2′-bipyridine derivatives via multi-component reaction under neat condition |
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Authors: | Prakasam Thirumurugan |
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Institution: | Organic Chemistry Division, Central Leather Research Institute, Adyar, Chennai 600 020, India |
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Abstract: | A series of 4-aryl-6-(1H-indol-3-yl)-2,2-bipyridine-5-carbonitrile derivatives were synthesized via a one-pot multi-component reaction of aromatic aldehydes, 3-(cyanoacetyl)indole and 2-acetyl pyridine in ammonium acetate by conventional heating and microwave irradiation under solvent-free condition. Also a series of 6,6′-di(1H-indol-3-yl)-4,4′-diaryl-2,2′-bipyridine-5,5′-dicarbonitrile derivatives were synthesized using cinnamils, 3-(cyanoacetyl)indole and ammonium acetate. The methodology affords high yields of product at short reaction time. |
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Keywords: | 6-(Indol-3-yl)-2 2&prime -bipyridine Multi-component reaction 3-Cyanoacetyl indole Neat condition 2 2&prime -Bipyridine Microwave irradiation Cinnamils |
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