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Amidation through carbamates
Authors:Antonio Latorre  Javier Izquierdo
Affiliation:Departament de Química Inorgànica, Universitat Jaume I, 12080 Castelló, Spain
Abstract:N-Alkyl carbamates of primary amines are easily converted into amides under treatment with Grignard reagents. Consequently, primary amines can be converted into amides in a one-pot reaction through carbamate protection and Grignard addition.
Keywords:Amides   Carbamates   Amines
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