Palladium-catalyzed coupling of vinyl tosylates with arylsulfinate salts |
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| Authors: | Diana C. Reeves Sonia Rodriguez Heewon Lee Nizar Haddad Dhileep Krishnamurthy Chris H. Senanayake |
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| Affiliation: | Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road/PO Box 368, Ridgefield, CT 06877-0368, USA |
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| Abstract: | The first palladium-catalyzed coupling of vinyl tosylates with arylsulfinate salts is described. A variety of cyclic and acyclic vinyl tosylates were coupled with aryl sulfinate salts using 2.5 mol % Pd2(dba)3/5.0 mol % XantPhos to give vinyl aryl sulfone products in good yields. The coupling was extended to the preparation of a cyclopropyl vinyl sulfone. |
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| Keywords: | Vinyl sulfones Vinyl tosylates Palladium Cross-coupling |
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