Specific recognition of a nucleobase-functionalized poly(3,4-ethylenedioxithiophene) (PEDOT) in aqueous media |
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| Authors: | Raúl Blanco Bazaco Carlos Seoane José L Segura |
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| Institution: | a Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, E-28040 Madrid, Spain
b Institute of Organic Chemistry II and Advanced Materials, University of Ulm, Albert Einstein Alee 11, 89081 Ulm, Germany |
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| Abstract: | In this Letter we report the synthesis, characterization, and electrochemical investigation of a 3,4-ethylenedioxythiophene (EDOT) derivative covalently linked to the nucleobase uracil. The successful electrochemical polymerization of this derivative has provided modified electrodes with a novel functional poly(3,4-ethylenedioxythiophene) derivative. Recognition experiments in aqueous media have shown the specific recognition of the complementary base adenine. The electrochemical detection of the selective binding of nucleobases to this PEDOT derivative in aqueous media can be of particular interest for electrochemical sensor applications in physiological media. |
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| Keywords: | PEDOT Nucleobases Hydrogen bond Electrochemistry |
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