Efficient organocatalytic α-sulfenylation of substituted piperazine-2,5-diones |
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Authors: | Ramin Dubey |
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Institution: | Department of Chemistry, The University of Arizona, Tucson, AZ 85721, United States |
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Abstract: | Organocatalytic α-sulfenylation of substituted piperazine-2,5-diones is reported through the use of cinchona alkaloids as Lewis bases and electrophilic sulfur transfer reagents. 1-Phenylsulfanyl1,2,4]triazole, a novel sulfur transfer reagent, gave excellent product yields with a number of substituted piperazine-2,5-diones under mild conditions. Catalyst loading, stoichiometry of sulfur electrophile, temperature, and solvent were optimized to achieve high product yields. |
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