Direct asymmetric aldol reactions in brine using novel sulfonamide catalyst |
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Authors: | Tsuyoshi Miura |
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Institution: | Faculty of Pharmacy, Chiba Institute of Science, 15-8 Shiomi-cho, Choshi, Chiba 288-0025, Japan |
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Abstract: | Direct asymmetric aldol reactions of aldehydes with ketones in the presence of a catalytic amount of sulfonamide 4 and trifluoroacetic acid afforded the corresponding anti-aldol products in moderate to excellent yields with 85-93% ee. |
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