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New types of potential BNCT agents, o-carboranyl aminoalcohols |
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| Authors: | Chai-Ho Lee Jong-Dae Lee Hiroyuki Nakamura Sang Ook Kang |
| Affiliation: | a Department of Bio-nanochemistry and Institute of Basic Natural Science, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea b Department of Chemistry, College of Natural Science, Chosun University, Dong-gu, Kwangju 501-759, Republic of Korea c Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo 171-8588, Japan d Department of Radiological Science, Jeonju University, Jeonju, Jeonbuk 560-759, Republic of Korea e Department of Chemistry, Korea University, Sejong Campus, Chungnam 339-700, Republic of Korea |
| Abstract: | o-Carboranyl aminoalcohols were synthesized using a standard Mannich reaction, and were tested for their anticancer properties using an in vitro test for CT26 cancer cells. The polar periphery of the aminoalcohols benefited from the high boron uptake in CT26 cancer cells with low toxicity, indicating their potential as BNCT agents. |
| Keywords: | Low cytotoxicity Water solubility Boron neutron capture therapy Boron accumulation o-Carboranylphenol derivatives |
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