Thiol addition to t-butyl methyl squarate. Efficient synthesis of novel sulfur-linked squaryl group-containing glutamate analogs |
| |
Authors: | Tetsuro Shinada Atsuko Yamasaki Keiko Shimamoto |
| |
Affiliation: | a Graduate School of Science, Osaka City University, Sugimoto, Sumiyoshi, Osaka 558-8585, Japan b Suntory Institute for Bioorganic Research, Shimamoto-cho, Osaka 618-8503, Japan |
| |
Abstract: | Novel sulfur-linked squaryl group-containing glutamate analogs were synthesized via addition and mono-substitution reactions of thiols to t-butyl methyl squarate (BMSQ: 7) in two steps. A glutamate analog prepared from Boc-l-Cys showed a potent binding affinity to KA/AMPA receptors. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|