One-step assembly of novel carbamoyl substituted 6-oxo-4,5,6,11-tetrahydropyrrolo[1,2-b][2,5]benzodiazocine |
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| Authors: | Victor V Potapov Alexandr V Nikitin |
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| Institution: | a Department of Organic Chemistry, Chemical Diversity Research Institute, 114401 Khimki, Moscow Reg, Russia
b ChemDiv, Inc., 6605 Nancy Ridge Drive, San Diego, CA 92121, USA |
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| Abstract: | In this work we have synthesized novel pharmaceutically relevant pyrrolo1,2-b]2,5]benzodiazocines based entirely on the use of MCR between heterocyclic aldehyde-acid, amines, and isonitriles. The developed synthetic strategy provides an efficient one-step route to rare heterocyclic scaffold of paramount interest. |
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| Keywords: | Ugi MCR 6-Oxo-4 5 6 11-tetrahydropyrrolo[1 2-b][2 5]benzodiazocine Parallel synthesis Compound library |
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