Synthetic studies toward the mitomycins: construction of the tetracyclic core via a reductive aminocyclization reaction |
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| Authors: | Daniel A. Gubler |
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| Affiliation: | a Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA
b University of Colorado Cancer Center, Aurora, CO 80045, USA |
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| Abstract: | The tetracyclic core of the mitomycin family of natural products has been formed in one step from an acyclic precursor via a reductive aminocyclization reaction. Additionally, the eight-membered benzazocine can be prepared without the need for prior activation of the aniline. Construction of a mitomycin K analogue lacking the C9a methoxy moiety is also reported herein. |
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