Sialylation reactions with N,N-acetyl, benzoyl-O-perbenzoyl-protected sialyl donor |
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| Authors: | Yue Wang |
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| Affiliation: | State Key Laboratory of Natural and Biomimetic Drugs, Peking University, and School of Pharmaceutical Sciences, Peking University, Xue Yuan Road #38, Beijing 100191, China |
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| Abstract: | A new sialyl donor, N,N-acetyl, benzoyl-O-perbenzoyl-protected p-toluenethiosialoside, was synthesized and its sialylation reaction was investigated. This reaction proceeded in dichloromethane and β anomeric selectivity was achieved when NIS-TfOH was used as promoter. This method may be employed to construct the unnatural β-linked sialosides. |
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| Keywords: | Sialylation Glycosylation Stereoselectivity Carbohydrate Synthetic method |
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