Microwave-assisted synthesis of 2-aminonicotinic acids by reacting 2-chloronicotinic acid with amines |
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Authors: | Camilo E Quevedo Edward McDonald |
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Institution: | Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK |
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Abstract: | 2-(Methylamino)nicotinic acid was readily prepared in high yield by reacting 2-chloronicotinic acid with 40% aq MeNH2 under microwave irradiation either at 120 °C for 2 h or at 140 °C for 1.5 h. Subsequently, we found that a range of 2-aminonicotinic acids could be obtained under microwave heating. The optimal reaction conditions involved the use of 3 equiv of amine, water as the solvent and heating at 200 °C for 2 h in the presence of diisopropylethylamine (3 equiv). |
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Keywords: | 2-Aminonicotinic acid Microwave irradiation 2-Chloronicotinic acid |
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