Synthesis of 22-oxaspiro[4.5]decane CD-ring modified analogs of 1α,25-dihydroxyvitamin D3 |
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| Authors: | Frederik De Buysser Annemieke Verstuyf |
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| Institution: | a Department of Organic Chemistry, Ghent University, Krijgslaan 281 S4, B-9000 Gent, Belgium
b Laboratory of Experimental Medicine and Endocrinology, Catholic University of Leuven, Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium |
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| Abstract: | In search of analogs of 1α,25-dihydroxyvitamin D3 featuring a dissociation of calcemic and other activities, a series of stereoisomeric 19-nor-22-oxa derivatives, characterized by a spiro4.5]decane cyclic system instead of the classical CD-ring system, have been synthesized in an enantioselective way. |
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| Keywords: | Spirocyclic decanones Calcitriol analogs Enantioselective synthesis |
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