A concise synthesis of indolic enamides: coscinamide A, coscinamide B, and igzamide |
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| Authors: | Yuelong Ma |
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| Affiliation: | Department of Molecular Medicine, Beckman Research Institute and Graduate School of Biological Sciences at City of Hope, Duarte, CA 91010, USA |
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| Abstract: | A concise synthesis of indolic enamides coscinamide A, coscinamide B, and the brominated tryptamine derivative igzamide is described. Both E- and Z-isomers of these natural compounds were obtained during the thermally assisted dehydration reaction and were tested for antitumor activity. Coscinamide B was found to possess antitumor activity against DU145 with an IC50 of 7.6 μg/mL. |
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| Keywords: | Indolic enamide Coscinamide A Coscinamide B Igzamide Dehydration reaction |
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