An expedient protocol for conversion of olefins to α-bromo/iodoketones using IBX and NBS/NIS |
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Authors: | Jarugu Narasimha Moorthy Kalyan Senapati Nidhi Singhal |
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Institution: | Department of Chemistry, Indian Institute of Technology Kanpur 208 016, India |
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Abstract: | A variety of olefins have been shown to undergo conversion to the corresponding α-bromo/iodoketones when reacted with NBS/NIS and IBX in DMSO at room temperature. While the reaction is found to occur rapidly with e-rich arylolefins leading to the corresponding haloketones in 65-95% yields in 0.3-3.0 h, those containing e-withdrawing groups are found to yield diketones concomitantly, such that the latter are the exclusive products over extended duration of the reactions. |
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