A new short synthesis of 5,6-dimethylxanthenone-4-acetic acid (ASA404, DMXAA) |
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| Authors: | Shangjin Yang William A Denny |
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| Institution: | Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand |
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| Abstract: | A new short synthesis of 5,6-dimethylxanthenone-4-acetic acid (ASA404) is developed. The key steps of the synthesis are dibromination of 3,4-dimethylbenzoic acid, followed by regioselective coupling with 2-hydroxyphenylacetic acid and subsequent cyclodehydration. |
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| Keywords: | ASA404 DMXAA Synthesis Anti-vascular agent |
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